Cagrilintide + Semaglutide
Also known as CagriSema
Cagrilintide and semaglutide combined. Novo Nordisk's next weight-loss injection, waiting for approval.
Quick facts
- Status
- Investigational — not approved yet
- Evidence
- Investigational (phase 3 REDEFINE trials)
- Taken as
- Injection under the skin once a week
- Sold as
- 10 mg blend sold online — not the clinical product.
- Category
- Blend · weight (investigational)
How it works
Two fullness signals at once — amylin and GLP-1 — for a bigger effect than either alone.
What people use it for
Weight loss (submitted for approval)
What the research shows
- Large phase 3 trials (REDEFINE) showed more weight loss than semaglutide alone.
- Submitted to the FDA in December 2025.
Side effects & risks
- Nausea, vomiting, diarrhoea and constipation
- Blends sold online are not the trial product
Is it legal?
Investigational — submitted to the FDA in December 2025 and not approved in the EU or US as of October 2026. "Blends" sold online are not the clinical product.
Storage & safe handling
- Mix with bacteriostatic water: let it run slowly down the inside of the vial and swirl gently — never shake.
- Store the mixed vial in the fridge and follow the use-by period on the label.
- Wipe the vial top with alcohol and use a new sterile needle and syringe every time.
- Rotate injection sites so the same spot is not used again and again.
- Put used needles in a sharps container, not the household bin.
- Get medical help for redness that spreads, fever, swelling or trouble breathing.
Open in PepTimerTrack your protocol, calculate how much to draw and get reminders — free.Open in PepTimer
Sources: Novo Nordisk REDEFINE phase 3 programme; FDA submission (December 2025). See the Semaglutide and Cagrilintide fact sheets.
Last updated 12 October 2026. Information — not medical advice. PepTimer does not replace a doctor. Many peptides are not approved medicines in the EU, UK or US. Talk to a qualified healthcare provider before starting, changing or stopping any treatment.
Last updated 12 October 2026. Information — not medical advice. PepTimer does not replace a doctor. Many peptides are not approved medicines in the EU, UK or US. Talk to a qualified healthcare provider before starting, changing or stopping any treatment.