Mazdutide
Also known as IBI362, LY3305677
A weekly weight-loss injection approved in China in 2025. It acts on both GLP-1 and glucagon.
Quick facts
- Status
- Not an approved medicine
- Evidence
- Approved in China (phase 3 trials)
- Taken as
- Injection under the skin once a week
- Common sizes
- 5 mg, 10 mg
- Category
- GLP-1/glucagon receptor agonist · weight
How it works
The GLP-1 part reduces hunger and helps blood sugar. The glucagon part may raise how much energy your body burns and reduce liver fat.
What people use it for
- Weight loss (approved in China)
- Type 2 diabetes (studied in China)
What the research shows
- Phase 3 trials in China showed meaningful weight loss.
- Not studied or approved in the EU or US.
Side effects & risks
- Nausea, diarrhoea and vomiting, mostly at the start
- Faster heart rate
- Products sold online outside China are unregulated
Is it legal?
Approved by China's NMPA (June 2025) for chronic weight management. Not approved in the EU, UK or US.
Storage & safe handling
- Mix with bacteriostatic water: let it run slowly down the inside of the vial and swirl gently — never shake.
- Store the mixed vial in the fridge and follow the use-by period on the label.
- Wipe the vial top with alcohol and use a new sterile needle and syringe every time.
- Rotate injection sites so the same spot is not used again and again.
- Put used needles in a sharps container, not the household bin.
- Get medical help for redness that spreads, fever, swelling or trouble breathing.
Open in PepTimerTrack your protocol, calculate how much to draw and get reminders — free.Open in PepTimer
Sources: Innovent announcement of NMPA approval (June 2025); GLORY-1 phase 3 trial.
Last updated 12 October 2026. Information — not medical advice. PepTimer does not replace a doctor. Many peptides are not approved medicines in the EU, UK or US. Talk to a qualified healthcare provider before starting, changing or stopping any treatment.
Last updated 12 October 2026. Information — not medical advice. PepTimer does not replace a doctor. Many peptides are not approved medicines in the EU, UK or US. Talk to a qualified healthcare provider before starting, changing or stopping any treatment.