PE-22-28

Also known as Mini-spadin

A shortened version of a peptide that acted as a fast antidepressant in mice.

Quick facts

Status: Not an approved medicine
Evidence: Preclinical (mouse studies)
Taken as: Nasal spray or injection
Common sizes: 10 mg
Category: Nootropic peptide (experimental)

How it works

It blocks a channel in brain cells (TREK-1) that is linked to depression in animal studies.

What people use it for

Mood and depression (claimed)

What the research shows

Only mouse studies.
No human data.

Side effects & risks

Unknown in humans
Should never replace proper treatment for depression

Is it legal?

Not an approved medicine in the EU, UK or US. In most countries it is illegal to sell it for use in people. Products labelled "research use only" are not checked for quality or purity.

Storage & safe handling

Mix with bacteriostatic water: let it run slowly down the inside of the vial and swirl gently — never shake.
Store the mixed vial in the fridge and follow the use-by period on the label.
Wipe the vial top with alcohol and use a new sterile needle and syringe every time.
Rotate injection sites so the same spot is not used again and again.
Put used needles in a sharps container, not the household bin.
Get medical help for redness that spreads, fever, swelling or trouble breathing.

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Sources: Djillani A et al., "Shortened spadin analogs display better TREK-1 inhibition", Front Pharmacol 2017.
Last updated 12 October 2026. Information — not medical advice. PepTimer does not replace a doctor. Many peptides are not approved medicines in the EU, UK or US. Talk to a qualified healthcare provider before starting, changing or stopping any treatment.